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Description:EGFR-kinaseinhibitor
ChemicalName:(R)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potentinhibitorofepidermalgrowthfactorreceptor(EGFR)kinase(IC50=0.4μM),moreactivethanthe(+)enantiomer(Cat.No.0579).SelectiveoverErbB2.
TechnicalData
M.Wt | 308.34 |
Formula | C18H16N2O3 |
Storage | Desiccateat+4°C |
CASNumber | 133550-32-0 |
PubChemID | 5328772 |
InChIKey | UMGQVUWXNOJOSJ-KMHUVPDISA-N |
Smiles | OC1=C(O)C=CC(C=C(C(N[C@H](C)C2=CC=CC=C2)=O)/C#N)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 9.25 | 30 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight308.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.24mL | 16.22mL | 32.43mL |
5mM | 0.65mL | 3.24mL | 6.49mL |
10mM | 0.32mL | 1.62mL | 3.24mL |
50mM | 0.06mL | 0.32mL | 0.65mL |
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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