These preformed fibrils of tau-441 may be used as a model for the pathogenic form of tau in numerous tauopathies. Sourced from E. coli, tau-441 fibrils were prepared and confirmed by thioflavin assay and electron microscopy, which shows an average size ranging from 50nm-200nm. Applications of this product range from in vitro studies on fibril formation and stability 1 to in vivo studies on cellular uptake, cell viability and pathway activation 2. This product is also suitable for use in mouse models for studies involving memory, neuronal health, or seeding and prion like spreading 3. Recent assessment of the Amyloid hypothesis has led to the realization that wildtype tau is accumulated in various tauopathies including Alzheimer’s disease, Pick’s disease, and progressive supranuclear palsy among others. Applied to either in vivo or in vitro experiments, these fibrils may be utilized to investigate the mechanism of various tauopathies.
rPeptide是一家生物化学公司，坐落于美国乔治亚州，与雅典毗邻。该公司研发试剂是市场领跑者。主要产品涉及领域为老年性痴呆症与帕金森综合症研究使用的重组蛋白，重组多肽，抗体以及试剂等等，并成为了该领域的领导者。同时，该公司提供一系列外包服务，从分子生物学，蛋白表达与蛋白纯化到13C与15N统一标记蛋白与多肽。rPeptide技术平台可解决可溶性多肽/蛋白（例如：β-淀粉样蛋白、廋蛋白、前胰岛素）在大肠杆菌中表达等历史性难题。
1、Beta-AmyloidPeptides β-淀粉样多肽系列产品
2、 Proteins 蛋白系列产品
3、 Labeledpeptides&proteins 标记多肽与标记蛋白系列产品
4、MonoclonalAntibodies 单克隆抗体系列产品
5、PolyclonalAntibodies 多克隆抗体
6、Bydisease 人类疾病相关产品
7、Contractservices 外包服务
7.1 RecombinantExpressionofPeptidesandProteins 多肽与蛋白重组表达
7.2 UniformLabelingofPeptidesandProteins 多肽与蛋白进行标记
7.3 SyntheticPeptideSynthesis 多肽合成
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