Isotype: Murine IgG1k
Immunogen: Recombinant human CD279
INFORMATION: Human CD279 (PD-1, Programmed death 1) is a 55 kd Ig superfamily member with sililarity to CD28 and CD152(CTLA-4). It is expressed on activated T and B and myeloid cells, and engagement by its ligands PD-L1 (CD274, B7-H1) or PD-L2 (B7-DC) can inhibit proliferation and cytokine expression. In mice blockade of PD-1 ligand interaction has been used to augment T cell anti cancer responses (3,4,5).
Anti-CD279 antibody clone ANC4H6 binds to CD279 present on PHA activated PBMC in FACS, and binds to recombinant CD279 in EIA. Pre incubation of recombinant CD279-coated plates with ANC4H6 blocks binding of biotinylated recombinant CD273 in EIA.
References:
1) Ishida et al. (1992) EMBO J 11(11):3887-95.
2) Carreno BM, M Collins, et al. (2001) Annu Rev Immunol 20:29.
3) MA Curran, Allison JP, et al. (2010) PNAS 107(9): 4275-80.
4) Mangsbo SM, TH Totterman, et al. (2010) J Immunotherapy 33(3):225.
5) Hirano F, L Chen, et al. (2005) Canc Res 65: 1089.
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血液保存液属于医疗器械的几类?
如果需要储液箱,那储液箱和微型定量泵之间用什么连接?是用管道吗?
为了使供输血用的血液能保存一定时间,加入适当的抗凝剂,并尽量防止在保存期发生变质而用的液体。为了防止因糖的消失引起活力降低,尚加入葡萄糖。ACD液(含柠檬酸三钠、柠檬酸、葡萄糖)一般用于血库。添加ACD的血液放在4—6℃条件下保存,可保存三周。另外为防止柠檬酸盐的过量可用加磷酸钠的CPD液。此外还设计了加乳酸钠的ACDL液。如果加入甘油等防冻剂则可长时间冷冻保存红细胞。
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