生命科学Tocris价格优惠美国Tocris Bioscience公司,Tocris/ERK5-IN-1/5393/10/10 mg,其它酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/ERK5-IN-1/5393/10/10 mg

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Tocris

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5393/10

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4000-520-616

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Description:PotentandselectiveERK5inhibitor

ChemicalName:11-Cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveERK5inhibitor;inhibitsEGFR-inducedERK5autophosphorylation(EC₅₀=90nM)andERK5enzymaticactivity(IC₅₀=162nM).Exhibitsatleast30-foldselectivityforERK5overLRRK2inacellbasedassay.AlsoselectiveforERK5overapanelofotherkinases.Orallybioavailable.

LicensingInformation

SoldunderlicensefromDana-FarberCancerInstitute.

CompoundLibraries

ERK5-IN-1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	638.8
Formula	C₃₆H₄₆N₈O₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1435488-37-1
PubChemID	71604307
InChIKey	XVBGRTMNFNMINE-UHFFFAOYSA-N
Smiles	O=C2N(C)C3=C(N=C(NC5=CC=C(C(N6CCC(N7CCN(C)CC7)CC6)=O)C=C5OCC)N=C3)N(C4CCCC4)C1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	63.88	100
	ethanol	63.88	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight638.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.57mL	7.83mL	15.65mL
5mM	0.31mL	1.57mL	3.13mL
10mM	0.16mL	0.78mL	1.57mL
50mM	0.03mL	0.16mL	0.31mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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