BiologicalActivity
PotentandselectivePFKFB3inhibitor(IC50=0.023μM).SelectiveforPFKFB3overPFKFB2andPFKFB1isoforms(IC50valuesare0.382μMand2.06μM,respectively).Reduceslevelsoffructose-1,6-bisphosphateinA549cells(IC50=0.343μM).Exhibitsnosignificantinhibitionofotherkinases.
TechnicalData
| M.Wt | 402.49 |
| Formula | C24H26N4O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1704740-52-2 |
| PubChemID | 118735769 |
| InChIKey | OOGHGWKBJXQNEJ-QFIPXVFZSA-N |
| Smiles | N#CC1=CN(CC(C)C)C2=C1C=C(OC3=CC=C(NC([C@H]4NCCC4)=O)C=C3)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.25 | 100 | |
| ethanol | 40.25 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight402.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.48mL | 12.42mL | 24.85mL |
| 5mM | 0.5mL | 2.48mL | 4.97mL |
| 10mM | 0.25mL | 1.24mL | 2.48mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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