BiologicalActivity
DNAmethylating,chemotherapeuticagent.Displaysantitumoractivityagainstaboardspectrumoftumors,includingleukemias,lymphomasandsolidtumors(IC50=5.0μMforcytotoxicityagainstmouseTLX5lymphomacells).Inducesautophagyinmalignantgliomacells.ExhibitsenhancedactivitywhenusedincombinationwithCHC(CatNo.5029).
CompoundLibraries
TemozolomideisalsoofferedaspartoftheTocriscreenPlus,TocriscreenEpigeneticsToolboxandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 194.15 |
| Formula | C6H6N6O2 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 85622-93-1 |
| PubChemID | 5394 |
| InChIKey | BPEGJWRSRHCHSN-UHFFFAOYSA-N |
| Smiles | CN1N=NC2=C(N=CN2C1=O)C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.71 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight194.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.15mL | 25.75mL | 51.51mL |
| 5mM | 1.03mL | 5.15mL | 10.3mL |
| 10mM | 0.52mL | 2.58mL | 5.15mL |
| 50mM | 0.1mL | 0.52mL | 1.03mL |
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