Tocris试剂采购 Tocris Bioscience授权代理商，正品,Tocris/FLI 06/5172/50/50 mg,细胞凋亡,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/FLI 06/5172/50/50 mg

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Tocris

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5172/50

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4000-520-616

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Description:InhibitorofNotchsignaling

ChemicalName:Cyclohexyl1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofNotchsignaling(EC₅₀=2.3μM).DisruptsNotchtraffickingandprocessing.Reducesamyloidβsecretion.ChangesthematurationandabolishesshreddingofAPP.InhibitsERexportingandconvertstubularERtosheets.

CompoundLibraries

FLI06isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	438.52
Formula	C₂₅H₃₀N₂O₅
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	313967-18-9
PubChemID	3103157
InChIKey	SWWVFYHSSOWZMF-UHFFFAOYSA-N
Smiles	O=C(OC3CCCCC3)C1=C(C)NC(CC(C)(C)CC4=O)=C4C1C2=CC=C([N+]([O-])=O)C=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	43.85	100
	ethanol	8.77	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight438.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.28mL	11.4mL	22.8mL
5mM	0.46mL	2.28mL	4.56mL
10mM	0.23mL	1.14mL	2.28mL
50mM	0.05mL	0.23mL	0.46mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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SolubilityData

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