COVID-19campusclosures:seeoptionsforRemoteAccesstosubscribedcontent.
GliaVolume61,Issue11
OriginalArticleSchwanncell‐derivedexosomesenhanceaxonalregenerationintheperipheralnervoussystemMaríaAlejandraLopez‐VerrilliMillenniumNucleusforRegenerativeBiology,FacultyofBiologicalSciences,PontificiaUniversidadCatolicadeChile,Santiago,Chile
SearchformorepapersbythisauthorFredericPicouMillenniumNucleusforRegenerativeBiology,FacultyofBiologicalSciences,PontificiaUniversidadCatolicadeChile,Santiago,Chile
SearchformorepapersbythisauthorFelipeA.CourtCorrespondingAuthor
MillenniumNucleusforRegenerativeBiology,FacultyofBiologicalSciences,PontificiaUniversidadCatolicadeChile,Santiago,Chile
NeurounionBiomedicalFoundation,Santiago,Chile
AddresscorrespondencetoFelipeA.Court,Av.B.O"Higgins340/Casilla114‐D,Santiago8331150,Chile.E‐mail:fcourt@bio.puc.cl
SearchformorepapersbythisauthorMaríaAlejandraLopez‐Verrilli
MillenniumNucleusforRegenerativeBiology,FacultyofBiologicalSciences,PontificiaUniversidadCatolicadeChile,Santiago,Chile
SearchformorepapersbythisauthorFredericPicouMillenniumNucleusforRegenerativeBiology,FacultyofBiologicalSciences,PontificiaUniversidadCatolicadeChile,Santiago,Chile
SearchformorepapersbythisauthorFelipeA.CourtCorrespondingAuthor
MillenniumNucleusforRegenerativeBiology,FacultyofBiologicalSciences,PontificiaUniversidadCatolicadeChile,Santiago,Chile
NeurounionBiomedicalFoundation,Santiago,Chile
AddresscorrespondencetoFelipeA.Court,Av.B.O"Higgins340/Casilla114‐D,Santiago8331150,Chile.E‐mail:fcourt@bio.puc.cl
SearchformorepapersbythisauthorGiveaccess
SharefulltextaccessSharefull-textaccess
PleasereviewourTermsandConditionsofUseandcheckboxbelowtosharefull-textversionofarticle.IhavereadandaccepttheWileyOnlineLibraryTermsandConditionsofUseShareableLinkUsethelinkbelowtoshareafull-textversionofthisarticlewithyourfriendsandcolleagues.Learnmore.
CopyURLSharealink
ShareonEmailFacebookTwitterLinkedInRedditWechatAbstractAxonalregenerationintheperipheralnervoussystemisgreatlysupportedbySchwanncells(SCs).Afternerveinjury,SCsdedifferentiatetoaprogenitor‐likestateandefficientlyguideaxonstotheiroriginaltargettissues.ContactandsolublefactorsparticipateinthecrosstalkbetweenSCsandaxonsduringaxonalregeneration.HereweshowthatdedifferentiatedSCssecretenano‐vesiclesknownasexosomeswhicharespecificallyinternalizedbyaxons.Surprisingly,SC‐derivedexosomesmarkedlyincreaseaxonalregenerationinvitroandenhanceregenerationaftersciaticnerveinjuryinvivo.Exosomesshiftthegrowthconemorphologytoapro‐regeneratingphenotypeanddecreasetheactivityoftheGTPaseRhoA,involvedingrowthconecollapseandaxonretraction.Altogether,ourworkidentifiesanovelmechanismbywhichSCscommunicatewithneighboringaxonsduringregenerativeprocesses.WeproposethatSCexosomesrepresentanimportantmechanismbywhichthesecellslocallysupportaxonalmaintenanceandregenerationafternervedamage.GLIA2013;61:1795–1806
AdditionalSupportingInformationmaybefoundintheonlineversionofthisarticle
Pleasenote:Thepublisherisnotresponsibleforthecontentorfunctionalityofanysupportinginformationsuppliedbytheauthors.Anyqueries(otherthanmissingcontent)shouldbedirectedtothecorrespondingauthorforthearticle.
Thefulltextofthisarticlehostedatiucr.orgisunavailableduetotechnicaldifficulties.
Pleasecheckyouremailforinstructionsonresettingyourpassword.Ifyoudonotreceiveanemailwithin10minutes,youremailaddressmaynotberegistered,andyoumayneedtocreateanewWileyOnlineLibraryaccount.
Can"tsignin?Forgotyourusername?
Enteryouremailaddressbelowandwewillsendyouyourusername
Iftheaddressmatchesanexistingaccountyouwillreceiveanemailwithinstructionstoretrieveyourusername
