产品名称多粘菌素B硫酸盐：PolymyxinBsulfatesalt——【产品编号：SIGMA-P4119】
Tips多粘菌素B为抗革兰阴性杆菌多肽类抗生素，可以改变膜结构使小分子物质泄漏而抑制革兰氏阴性菌的生长。分子式C55H96N16O132H2SO4分子量1385.61储存条件2-8C冷藏保存。
AntibioticwithbactericidalactiononE.coli.3,4BindstothelipidAportionofbacteriallipopolysaccharides.5Inducesporeformationinthemembranesofcortexcellsfromexcisedsorghumroots.6
ModeofAction:BindstoandinterfereswiththepermeABIlityofthecytoplasmicmembrane.
Antimicrobialspectrum:Gram-negativebacteria.PolymyxinBdestabilizesanddisruptscellmembraneintegritywhichallowstheleakageofcellularmoleculesandinhibitscellularrespiration.Inhumandendriticcells,DCsincubatedwithpolymyxinBup-regulatetheexpressionofHLAclassIandII,theco-stimulatoryCD86molecule,andshowanincreaseinthefractionofadherentcells1.Intheratmodel,PolymyxinBcausedasignificantreductioninplasmaendotoxinandtumournecrosisfactor(TNF-)concentration.2.OtherNotesMixtureofPolymyxinB1andB2sulfate.ApplicationPolymyxinBisalipopolysaccharidebindingantibioticderivedfromBacilluspolymyxa.ItisprimarilyusedagainstGram-negativebacteria.Itisusedtomaturedendriticcellsincultureandinactivatepotentiallipopolysaccharidecontaminations.PolymyxinBisusedtostudypotentialtreatmentsforsepticshock1andforantimicrobialsusceptibilitytestingoforganismssuchasPseudomonasaeruginosa2.PolymyxinBsulfatesaltisbiotechnologyperformancecertified.
参考文献

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